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. 2017 Dec 5;11:111. doi: 10.3389/fnana.2017.00111

FIGURE 1.

FIGURE 1

Cytoarchitecture of the perinatal human insula. (A) Classification of the insular areas of Von Economo and Koskinas (1925). IA, anterior agranular, IB: posterior granular, IAB intermediate dysgranular areas. (B) Left insular lobe of a newborn infant (40 GW) after removing the anterior temporal pole. A1, A2, anterior short gyri; Ac: accessory short gyrus; P1, P2, posterior long gyri; CS: central sulcus of the insula. (C) Dissection of the insula in B. The line indicates the plane of section. (D–F) Nissl-stained sections from the brain in B,C. (D) IC, the agranular transition area between the POC and the isocortical insula; (E) Area IA, representing the dysgranular area, with an irregular layer IV; (F) area IB, the granular posterior insula. Notice that layer II is still cell-dense and not yet fully mature. (G–I) 32 GW. (G) Transition between POC and isocortical insula showing ill-defined layering. (H) A poorly developed layer IV in the dysgranular insula; (I) A wide, cell-rich layer IV in the granular insula. Bars: in F, for D–F: 160 μm; in G: 50 μm; in I, for H and I: 55 μm.