Table 2.
Research in normal/disease states | Intervention | Effects | Reference |
---|---|---|---|
Normal | Delta(9)-THC | ↓ GLAST/GLT-1, ↓ glutamate uptake | Castaldo et al., 2010 |
Normal | Ochratoxin A | ↓ GLAST/GLT-1, ↓ glutamate uptake | Razafimanjato et al., 2010 |
Normal/hypoxic | BDNF/CoCl2 | ↑ GLAST, ↑ glutamate uptake | Dai et al., 2012 |
Alcohol consumption | Per2 mutant | ↓ GLAST, ↑ intraparenchymal glutamate | Spanagel et al., 2005 |
Normal | Antisense oligonucleotide | ↓ GLAST/GLT-1, ↑ intraparenchymal glutamate | Rothstein et al., 1996 |
Hearing loss | GLAST KO | ↓ GLAST, ↑ intraparenchymal glutamate | Hakuba et al., 2000 |
Normal | Morphine | ↓ EAAT3, ↑ extracellular glutamate | Guo et al., 2015 |
BDNF, brain-derived neurotrophic factor; KO, knock out.