Table 1.
Overview of acquired antibiotic resistance genes among the 101 A. salmonicida subsp. salmonicida sequenced isolates and the reference A449.
| A. salmonicida subsp. salmonicida isolate | Beta-lactam | Trimethoprim | Sulphonamide | Aminoglycoside | Phenicol | Tetracycline | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference A449 (France 1975) | blaFOX-2 | ampS | blaCEPH-A3 | – | – | sul1 | – | – | – | aadA1 | – | cat | tet(E) |
| Sd5 2005 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Mj10 2009 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Mj10 2010 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Nj1 2011 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | strB | aadA1 | strA | – | – |
| Mj11 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Mj3 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Sj4 2014 | blaFOX-2 | ampS | blaCEPH-A3 | dfrA14 | – | – | sul2 | – | strB | – | strA | – | – |
| Mj10 1982 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | sul1 | – | aadA2 | – | – | – | – | – |
| Mj8 1997 | blaFOX-2 | ampS | blaCEPH-A3 | – | dfrA1 | sul1 | – | – | – | aadA1 | – | – | – |
| Nj2 2001 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj22 2002 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Nj4 2002 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj11 2003 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 2003 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd1 2004 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd4 2004 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 2004 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj7 2008 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj16 2008 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj4 2008 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 2008 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (a) 2009 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 (a) 2009 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 (b) 2009 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (b) 2009 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 2010 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (a) 2010 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (b) 2010 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 2011 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj9 2012 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj12 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd6 (a) 2013 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd6 (b) 2013 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj14 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd4 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd10 2014 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj7 1980 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj24 1980 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj18 1981 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj7 1981 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1981 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj16 1981 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd3 1982 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1982 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd2 1982 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1983 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj6 1983 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj15 1983 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd2 1983 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj7 1984 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj15 1984 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Nj3 1984 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj16 1985 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj5 1986 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj18 1986 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj16 1986 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj11 1987 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj16 1987 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj13 1987 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj5 1988 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1988 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd9 1988 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj11 1988 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj1 1989 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 1989 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj2 1990 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 1990 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj20 1990 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj5 1990 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Scotland | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj3 1991 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Nj5 1991 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj5 1991 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj18 1991 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1992 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj1 1992 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd8 1992 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj6 (a) 1993 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj6 (b) 1993 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj2 (a) 1993 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj2 (b) 1993 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj21 1993 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj19 1994 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj5 1994 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Nj3 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj12 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj1 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj4 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj5 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd2 1995 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj23 (a) 1996 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj23 (b) 1996 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj6 (a) 1996 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj6 (b) 1996 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sd7 1997 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj20 1997 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 1998 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (a) 1999 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Mj17 1999 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| Sj4 (b) 1999 | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
| NCIMB 1102 (Type strain 1962) | blaFOX-2 | ampS | blaCEPH-A3 | – | – | – | – | – | – | – | – | – | – |
Threshold for presence of a resistance gene in an isolate was set to 75% similarity expressed as percent sequence identity (ID) and 60% of alignment length (coverage) of the resistance gene. Isolates are labeled according to region and year of isolation as in Figure 1.