Table 1.
Dark-adapted retinal light responses (Data for Figures 4B–E).
| Light intensity (cd·s/m2) | a-wave amplitude (μV) | a-wave implicit time (ms) | ||||
|---|---|---|---|---|---|---|
| WT | Cav1.3+/− | Cav1.3−/− | WT | Cav1.3+/− | Cav1.3−/− | |
| 0.1 | 123.4 ± 8.0 | 96.9 ± 7.5 | 74.0 ± 10.4* *p = 0.001 |
22.3 ± 0.4 | 26.0 ± 1.1# #p = 0.037 |
26.8 ± 1.5* *p = 0.020 |
| 0.3 | 184.4 ± 15.0 | 137.5 ± 8.8# #p = 0.01 |
96.8 ± 8.1*& *p = 0.00002 &P = 0.042 |
20.0 ± 0.6 | 24.8 ± 0.7# #p = 0.00008 |
24.3 ± 1.1* *p = 0.001 |
| 1 | 193.4 ± 9.2 | 153.0 ± 8.8# #p = 0.008 |
113.9 ± 10.4* *p = 0.000004, &P = 0.017 |
15.8 ± 0.8 | 19.2 ± 0.9# #P = 0.040 |
19.4 ± 1.4 |
| 3 | 243.4 ± 14.8 | 187.7 ± 9.9# #p = 0.006 |
134.9 ± 13.1*& *p = 0.000002, &P = 0.015 |
10.6 ± 0.3 | 13.6 ± 0.8# #p = 0.011 |
13.4 ± 0.9* *p = 0.036 |
| 10 | 278.7 ± 16.2 | 224.3 ± 11.7# #p = 0.016 |
157.2 ± 13.7*& *p = 0.000002, &p = 0.005 |
9.8 ± 0.3 | 12.6 ± 0.5# #p = 0.003 |
12.3 ± 0.9* *p = 0.015 |
| 25 | 303.5 ± 18.6 | 241.2 ± 12.3# #p = 0.011 |
174.4 ± 14.0*& *p = 0.000003, &p = 0.01 |
8.4 ± 0.3 | 10.4 ± 0.4# #p = 0.002 |
9.9 ± 0.5* *p = 0.036 |
| Light intensity (cd·s/m2) | b-wave amplitude (μV) | b-wave implicit time (ms) | ||||
| WT | Cav1.3+/− | Cav1.3−/− | WT | Cav1.3+/− | Cav1.3−/− | |
| 0.1 | 534.5 ± 35.6 | 392.2 ± 28.7# #p = 0.004 |
278.6 ± 23.2*& *p = 0.000005, &p = 0.035 |
34.4 ± 0.6 | 43.8 ± 2.2# #p = 0.003 |
43.7 ± 2.6* *p = 0.007 |
| 0.3 | 665.6 ± 38.6 | 453.6 ± 31.2# #p = 0.00008 |
336.5 ± 25.8*& *p = 0.0000001 &p = 0.049 |
32.5 ± 0.6 | 40.2 ± 1.8# #p = 0.004 |
39.7 ± 2.1* *p = 0.015 |
| 1 | 671.3 ± 36.9 | 488.0 ± 30.9# #p = 0.0005 |
353.7 ± 28.4* *p = 0.0000002, &p = 0.019 |
31.1 ± 0.6 | 37.1 ± 1.1# #p = 0.001 |
36.9 ± 1.8* *p = 0.005 |
| 3 | 680.4 ± 36.5 | 508.8 ± 31.4# #p = 0.003 |
347.1 ± 40.7*, & *p = 0.0000005, &p = 0.008 |
30.1 ± 0.5 | 35.5 ± 1.0# #p = 0.001 |
36.1 ± 1.7* *p = 0.002 |
| 10 | 833.0 ± 45.4 | 616.1 ± 35.9# #p = 0.0007 |
440.5 ± 35.5*, & *p = 0.0000001, &p = 0.010 |
31.3 ± 0.7 | 37.3 ± 0.9# #p = 0.0001 |
36.8 ± 1.3* *p = 0.001 |
| 25 | 874.7 ± 47.9 | 655.3 ± 36.4# #p = 0.001 |
470.8 ± 39.9*, & *p = 0.0000002, &p = 0.010 |
30.2 ± 0.6 | 36.1 ± 0.8# #p = 0.00004 |
35.9 ± 1.2* *p = 0.0004 |
*
Denotes Cav1.3−/− significantly different from WT.
#
Denotes Cav1.3+/− significantly different from WT.
&
Denotes Cav1.3−/− significantly different from Cav1.3+/−.
Significance was determined when one-way ANOVA Tukey post hoc tests achieved *p < 0.05.