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. 2017 Dec 5;8:1000. doi: 10.3389/fphys.2017.01000

Figure 1.

Figure 1

Bowel obstruction induced mechano-transcription of COX-2 selectively in the SMC. (A) Western blot detection of COX-2 in the colonic muscularis externa in the oral (left) and aboral (right) segments. (B) Western blot detection of COX-2 in the mucosa/submucosa in the oral (left) and aboral (right) segments. (C) Immunohistochemical staining of COX-2 expression in the oral (a,c) and aboral (b,d) colon segments in sham control (a,b) and rat with obstruction (c,d) for 3 days. Note that COX-2 (stained in brown) is detected only in SMC in distended oral segment. The results were representative of four independent experiments. Calibration bars represent 50 μm. Figure is adapted with permission from Shi et al. (2011) (PMCID: PMC3025501).