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Cell signaling mechanisms of mechano-transcription of COX-2 in colon SMC. Mechanical stretch on gut SMC is sensed by integrins and SAC (stretch-activated ion channels) at the cell membrane level. The mechano-sensors transduce mechanical stimulus to intracellular signaling pathways involving PKC (PKCdelta), PKD (PKD1), and MAPKs to induce mechano-transcription of COX-2 in colonic SMC. PKCdelta is coupled to MAPKs ERKs, p38, and JNKs, whereas PKD1 is coupled to MAPK p38.
