Table 3.
Positive selection sites in the present strains of HuNoV GII.4.
| Amino acid changes | SLAC | FEL | IFEL |
|---|---|---|---|
| Asn6Ser | ° | ° | ° |
| Ser6Asn | |||
| Asn9Ser, Thr, His, Lys | ° | ° | ° |
| Ser9Asn | |||
| Asn17Ser, His, Thr | ° | ||
| Ala294Val, Thr, Pro, Gly | ° | ||
| Val294Gly, Ala | |||
| Thr294Ala, Ile, Ser | |||
| Pro294Ser, Thr | |||
| Ser294Pro, Ala | |||
| Gly294Arg | |||
| Tyr352Ser, Arg, Phe, Leu | ° | ||
| Ser352Tyr, Leu | |||
| Leu352Phe | |||
| Thr368Ser, Ala, Asn | ° | ||
| Ala368Val, Ser, Thr, Asp | |||
| Ser368Gly, Asn, Arg | |||
| Gly368Ala, Ser | |||
| Asn368Glu, Asp, Ser | |||
| Glu368Ala, Gly | |||
| Val368Phe | |||
| Glu376Gln, Asp, Val | ° | ||
| Gln376Glu, Asn | |||
| Asp376Glu, Val, Gly | |||
| Val376Glu, Ile | |||
| Gly393Ser, Asn, Asp | ° | ° | |
| Asn393Asp, Ser, Gly | |||
| Ser393Asn, Gly, Thr, Ala | |||
| Asp393Asn, Gly, Glu | |||
| Thr395Asn, Ala | ° | ° | |
| Asn395His, Thr | |||
| His395Arg, Asp, Pro | |||
| Ala395Thr | |||
| Val413Gly, Ala, Ile | ° | ||
| Gly413Ser, Val, Asn | |||
| Ser413Thr, Asn, Gly | |||
| Thr413Ser, Ile, Ala | |||
| Ile413Thr, Val | |||
| Ser494Thr, Pro, Ala | ° | ||
| Thr494Ala | |||
| Thr534Ala, Ser | ° | ° | ° |
| Ala534Val, Thr | |||
| Total | 5 | 6 | 9 |
Mean dN/dS = 0.130 (95%CI = 0.124–0.136).
p-value < 0.05.