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. 2017 Dec 5;11:91. doi: 10.3389/fncir.2017.00091

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Copyright © 2017 Vijayraghavan, Major and Everling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of dopamine receptor manipulations on PFC activity encoding rules in a numerosity judgment task. All panels adapted with permission from Ott et al. (2014). (A) Rule-guided numerosity judgment task used in Ott et al. (2014). Macaques had to use a rule (“greater than” or “less than”) cued by a colored dot or drops of juice to determine if a test numerosity panel displayed after a delay had more or less dots than a previously presented sample numerosity panel. The animals responded by holding or releasing a lever, based on their trial numerosity judgment. (B) Effects of D1R stimulation (top panel), D1R blockade (middle panel) and D2 receptor (D2R) stimulation (bottom panel) on normalized activity of PFC neurons showing differential responses to the trial rule. D1R stimulation and D2R stimulation augmented selectivity in rule representation, while D1R blockade suppressed population rule selectivity.