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. 2017 Dec 5;11:91. doi: 10.3389/fncir.2017.00091

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Copyright © 2017 Vijayraghavan, Major and Everling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of D1R agonist and D2R agonist on population activity of PFC neurons recorded during the performance of the rule-guided pro- and antisaccade task. All panels adapted with permission from Vijayraghavan et al. (2016). (A) Recording locus (left) and the pro- and antisaccade task are shown. Subjects maintained central fixation, and a briefly presented colored cue indicated the rule to employ in the trial. This information was maintained in working memory (WM). After a brief gap post-fixation point offset, a peripheral stimulus was presented and monkeys had to use the previously remembered rule to make a saccade towards or away from the stimulus. In another version of the task employed in Vijayraghavan et al. (2016), the rule was uncued and the subjects had to derive the trial rule based on reward feedback and maintain this rule was a block of trials. Blocks of prosaccade trials alternated with blocks of antisaccade trials and the subjects learned to switch response types based on feedback. (B) D1R stimulation (left panel) with iontophoresis of full D1R agonist SKF81297 suppressed the population activity of PFC neurons, while D2R stimulation with D2R agonist quinpirole (right panel) increased population activity.