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. 2017 Dec 5;11:91. doi: 10.3389/fncir.2017.00091

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Copyright © 2017 Vijayraghavan, Major and Everling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of D1R stimulation on rule selectivity of PFC neurons. All panels adapted with permission from Vijayraghavan et al. (2016). (A) Iontophoretic stimulation of D1R (middle panel) suppressed the activity of a PFC neuron that had more prestimulus activity during prosaccade trials. Rule selectivity of the neuron was diminished, and recovered upon cessation of drug application (bottom panel). Blue traces and rasters: prosaccade trials; Red traces and rasters: antisaccade trials. (B) D1R stimulation decreased PFC population rule selectivity (top panel) assessed by signal detection theory. The area under the receiver operating characteristic curve (AUROC) for individual rule-selective neurons tested is plotted for control (abscissa) and during D1R stimulation (ordinate). Drug application shifted the AUROCs below the equality line (dashed line) indicating reduction in population rule selectivity. D1R stimulation at both low and high doses reduced population rule selectivity, with greater reduction for higher doses (bottom panel). Blue dots represent neurons with greater activity for the prosaccade rule and red dots, neurons with greater activity for the antisaccade rule.