Table 1.
Clinical summary of events.
| Days | Initial fungal burden (CFU/mL) | Doses of amphotericin | Final fungal burden (CFU/mL) | Fluconazole dose (mg/day) | Diagnosis |
|---|---|---|---|---|---|
| 0 | Not done | 0 | Not done | 400 mg | Primary CM |
| 60 | 80 | 10 | Sterile | 800 mg for 2 wks/400 mg for 10wks/200 mg | Untreated CM |
| 180 | 93,000 | 14 | 21,000 | 1200 mg | CM Relapse |
| 240 | 58,000 | 3 | Not done | 1200 mg | Persistent CM |
| 330 | Not done | 14 | 110 | 1200 mg | Persistent CM |
| 360 | Not done | 8 | Sterile | 1200 mg | Persistent CM |
| 480 | Sterile | 0 | Not done | 800 mg | IRISa vs. Sepsis |
a
During the last hospitalization a diagnosis of either paradoxical immune reconstitution inflammatory syndrome vs. severe sepsis was made. CSF cultures at this time were sterile and CM relapse was ruled out.