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. 2017 Nov 1;10:9–27. doi: 10.1016/j.omtn.2017.10.019

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Effect of Anticancer Drugs Entrapped in PC-SA Liposomes on Cancer Cell Lines In Vitro following 2 hr Treatment

Camptothecin (CPT) at a molar ratio of 7 (PC):2 (SA):0.7 (CPT) and doxorubicin (DOX) at a molar ratio of 7 (PC):2 (SA):0.5 (DOX) showed 100% and 50% entrapment efficiency, respectively, in PC-SA liposomes. The EC₅₀ values of DOX entrapped in PC-SA are 500-fold lower than that of free DOX (p < 0.0001) with respect to free DOX. Similarly, the EC₅₀ values of CPT entrapped in PC-SA liposomes are 1,000-folds lower than that of free irinotecan HCl (a semisynthetic derivative of CPT) (p < 0.0001) with respect to free drug. The EC₅₀ values of DOX or CPT entrapped in PC-SA liposomes with respect to PC are significantly lower than that of free liposomes (p < 0.05 to p < 0.0001). All data represent the mean of triplicate experiments, with error bars indicating the SEM.