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. 2017 Dec 5;11:549. doi: 10.3389/fnhum.2017.00549

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Copyright © 2017 Zhang, Liao, Yao, Hu, Xie, Zheng, Hu, Zhao, Yang, Zhang, Su, Li, Gutknecht and Majoe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histogram of frequency distribution between two groups. The histograms of the HWF distributions show the first four intrinsic mode functions (IMFs) of each voxel in the whole-brain gray matter across all participants in each group by using the CEEMDAN approach. Each of the sub-histograms in corresponding IMFs displays amount of the whole-brain gray matter voxels within the GAD (A) and HC (B) group, respectively. Vertical axis represents the percentage of the number of voxels with HWF equal to the frequency on the horizontal axis in the whole-brain gray matter. The rectangular bar with different colors represents the frequency bands of the final selected FOIs. Colors assigned in the sequence of blue, cyan, green, and yellow represent FOI-1 (0.045–0.078 Hz), FOI-2 (0.02–0.036Hz), FOI-3 (0.01–0.019 Hz), and FOI-4 (0.003–0.01 Hz), respectively.