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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: J Control Release. 2017 Oct 5;266:248–255. doi: 10.1016/j.jconrel.2017.09.043

Figure 4.

Figure 4

Up-regulation of immune activity evident within TUBO tumors 48 hrs following radiation-enhanced delivery of amph-CpG. A) The increase in circulating monocytes seen after radiation-enhanced delivery coincided with an observed macrophage increase in tumor sections by IHC (brown = F4/80, macrophages). B) CD8+ T lymphocytes in tumor sections displayed increased Granzyme B immunoreactivity (brown) after IR. C) NK cell activity (brown = IFNγ) appeared up-regulated in tumor sections following IR + amph-CpG. In all IHC images, purple = hematoxylin, nuclei. Scale bar = 100 μm. Inset = 4X zoom. Qualitative scoring: (−−−) negative, (+) faint staining of some cells, (++) moderate staining of many cells, (+++) intense staining of many cells. Representative images shown of n = 3 tumors per data set stained.