. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Curr Opin Chem Biol. 2017 Oct 20;41:20–27. doi: 10.1016/j.cbpa.2017.10.002

Table 1.

Ribosomal RNA methylating enzymes associated with antibiotic resistance in bacteria, where resistance is conferred by the absence of specific methylations of RNA nucleobases.

Gene encoding methylating enzyme	Methylated nucleotides (E. coli numbering)	Position of methylation	Antibiotic resistance phenotype
rlmN	A2503, 23S rRNA	C2	Linezolid
			Tiamulin
			Virginiamycin M₁

rlmA¹	G745, 23S rRNA	N1	Viomycin

rlmA¹¹	G748, 23S rRNA	N1	Telithromycin

ksgA	A1518 & A1519, 16S rRNA	N6, N6	Kasugamycin

rsmG	G527, 16S rRNA	N7	Streptomycin