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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: J Control Release. 2017 Sep 20;266:129–139. doi: 10.1016/j.jconrel.2017.09.024

Figure 1. Design and fabrication of T-MOC to simulate the drug transport at the TME.

Figure 1

(A) Schematic of the fabricated T-MOC platform and its operating pressure conditions. Detailed 3D configuration of the device is illustrated in cross-sectional view – top layer with capillary channel, nanoporous membrane, and bottom layer with interstitial and lymphatic channels. This design is to mimic a pair of capillary-lymphatic vessels with tumor tissues. (B) 3D morphology of breast cancer cells grown on the T-MOC: MCF-7 and MDA-MB-231. Comparison of growth rate of MCF-7 and MDA-MB-231 under 2D culture and 3D T-MOC culture configurations.