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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurotoxicology. 2017 Jun 10;64:85–93. doi: 10.1016/j.neuro.2017.06.006

Figure 2. Quadratic correlation between prenatal Mn (log) and functional connectivity with the right globus pallidus of 6–7-year-old children.

Figure 2

Note. A seed-based correlation analysis was performed. (A) the right globus pallidus seed region is displayed in the top row, while the brain areas that showed reduced functional connectivity with this seed region (i.e., the frontal pole, inferior frontal gyrus and middle frontal gyrus; depicted in red) are displayed in the bottom row. (B) Quadratic association between prenatal manganese exposure (x-axis) and functional connectivity (r) of the right globus pallidus seed with the frontal pole (y-axis). In order to compute the functional connectivity with the seed for each subject, we masked the significant activation (displayed in red in figure 2A) with the corresponding region from the probablistic Harvard-Oxford cortical atlas (i.e., frontal pole). We calculated the mean r value for this region using matlab and python scripts.