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. 2017 Dec 6;5:75. doi: 10.3389/fbioe.2017.00075

Figure 3.

Figure 3

Differences in relative expression of chondrogenic markers COL1A1, COL2A1, MMP3 (A–C), and the differentiation index (D) depicted to day 0 control under normoxic (20% O2) conditions. Matrix metalloproteinase 13 (MMP13) expression significantly downregulated under hypoxia (1% O2) than in normoxia (20% O2) (E) as determined by reverse transcriptase quantitative real-time PCR of OA chondrocytes cultured in FCS, hyperacute serum (HAS), or platelet-rich plasma (PRP). Significant difference at *p < 0.05; n = 3 biological replicates.