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. 2017 Dec 6;8:1691. doi: 10.3389/fimmu.2017.01691

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Copyright © 2017 Liao, Yu, Li, Yue, Tao, Su and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autoreactivity of monoclonal antibodies (mAbs) cloned from circulating plasmablasts of control and chronically HIV-infected individuals. (A) Representatives of autoantibodies (ANA) patterns of non-autoreactive Ab U78Ab3 from control and autoreactive Ab HIV201B2 from patient (scale bar: 10 µm). (B) Shown are pie charts summarizing the frequencies of autoreactive (black) and non-autoreactive (white) Abs. The percentages of ANAs in control and HIV-positive group are summarized in the bottom panel. (C) Shown is pie graph summarizing the percentages of nucleus- (black) and cytoplasmic-reactive (white) Abs in total of 40 ANAs.(D) Shown is pie graph summarizing the percentage of gp140-binding Abs (black) and non-gp140-binding Abs (white) in total of 40 ANAs. (E) Comparison of OD450_nm values in dsDNA-ELISA between ANAs and non-ANA. Red error bars indicate mean with SEM.