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. 2017 Dec 6;8:1691. doi: 10.3389/fimmu.2017.01691

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Copyright © 2017 Liao, Yu, Li, Yue, Tao, Su and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VH, DH, and JH gene usages, HCDR3 length, and VH mutation rate of Ig heavy (IgH) genes derived from plasmablasts controls and chronically HIV-infected individuals. (A–C) VH (A), DH (B), and JH (C) gene usages of the IgH genes. (D) Analyses of the IgH CDR3 lengths (amino acid, aa) of the predicted encoding Abs. (E) Comparison of VH somatic mutation rates between IgH genes derived from control donors and chronically HIV-infected individuals. Red error bars indicate mean with SEM. P-value was determined by unpaired t-test.