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. 2017 Dec 6;8:1691. doi: 10.3389/fimmu.2017.01691

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Copyright © 2017 Liao, Yu, Li, Yue, Tao, Su and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VH replacement analyses of Ig heavy (IgH) genes derived from plasmablasts of control and chronically HIV-infected individuals. (A) Shown is bar graph summarizing the frequencies of VH replacement products in IgH gene sequences derived from plasmablasts of each control donor (white bars) and HIV-infected individual (black bars). (B) Comparison of the IgH CDR3 lengths of non-VH replacement products (white bar; average ± SD: 14.01 ± 0.2705 aa) and VH replacement products (black bar; average ± SD: 16.05 ± 0.6439 aa). (C) Bar graph shows the frequency of aa contributed by the identified VH replacement footprints versus that in the N1 regions of non-VH replacement products. (D–F) Pie graphs show the percentage of polyreactive (D) autoreactive (E) and anti-gp140 (F) Abs encoded by VH replacement products.