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. 2017 Dec 6;8:1716. doi: 10.3389/fimmu.2017.01716

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Copyright © 2017 Hellmann, Lother, Wurster, Lutz, Schmitt, Morton, Eyrich, Czakai, Einsele and Loeffler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct cytokine response pattern to Aspergillus fumigatus by human and murine macrophages. Cytokine patterns in culture supernatants of human and murine macrophages were studied by a 13-plex cytokine assay upon 12 h stimulation with A. fumigatus conidia or germ tubes as well as depleted zymosan (dZym), LPS, or Pam3CSK. Four human (white bars) and four murine (black bars) samples were assessed. Mean concentrations of IL1β (A), IL10 (B), IL6 (C), IL8/Groα (D), MIP1α (E), and TNFα (F) are shown. Error bars indicate standard deviations. Significance was calculated as difference to unstimulated with ANOVA and Tukey post-test (stars above of bars) as well as between human and mouse specimens with unpaired t-test.