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. 2017 Dec 6;8:1716. doi: 10.3389/fimmu.2017.01716

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Copyright © 2017 Hellmann, Lother, Wurster, Lutz, Schmitt, Morton, Eyrich, Czakai, Einsele and Loeffler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct cytokine response patterns to Aspergillus fumigatus are observed in human and murine dendritic cells (DCs). Cytokine concentrations (picograms/milliliter) in culture supernatants of human moDCs and murine bone marrow-derived dendritic cells stimulated with ethanol-inactivated A. fumigatus conidia or germ tubes, depleted zymosan (dZym) or LPS were quantified by 13-plex cytokine assays. Four human (white bars) and four murine (black bars) DC samples were assessed. Mean concentrations of TNFα (A), IL12p70 (B), IL23 (C), IL6 (D), IL10 (E), IL18 (F), and IL1β (G) are shown. Error bars indicate standard deviations. Significance was calculated as difference to unstimulated specimens with ANOVA and Tukey post-test (stars above of bars) as well as between human and mouse specimens with unpaired t-test.