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. 2017 Dec 6;7:504. doi: 10.3389/fcimb.2017.00504

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Copyright © 2017 Biswas, Wagner Mackenzie, Waldvogel-Thurlow, Middleditch, Jullig, Zoing, Taylor and Douglas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The distribution of proteins at (A) cellular and (B) subcellular levels. The number of proteins within each group were averaged and represented as a percentage of total proteins. Proteins that could not be assigned to the chosen categories or were non-specified on the protein databases were placed into a separate “other/non-specified” group in (A). Proteins originating from blood or epithelial/goblet cells were differentially regulated (p < 0.05, t-test) in the CRS and healthy cohorts. At a subcellular level (B), significantly fewer proteins originated from the nucleus and mitochondrion of CRS patients compared with healthy controls.