Figure 2.

Immunohistochemistry staining of tissue sections. Tissue stains were compared with positive controls on the The Human Protein Atlas. (A,B) are representative images of middle meatus tissue biopsies from patients with CRS and healthy controls, respectively, stained with an antibody targeting protein PRRC2C. The protein PRRC2C was highly abundant in the epithelial cells, evident from the dark brown staining for CRS patients. (C,D) are representative of middle meatus tissue biopsies from patients with CRS and healthy controls, respectively, stained with an antibody targeting protein RAB14. RAB14 staining was observed within epithelial cells and macrophages of CRS patients with lighter staining within glands in healthy controls. Staining intensity is suggestive of protein abundance. Negative controls with no antibody did not show any staining. Grading stain intensity scores (E) were averaged across the samples for each cohort and shown as a percentage in the bar chart.