Table 2.

List of the seven significantly higher abundant proteins in the CRS cohort, compared with healthy controls.

Significantly elevated proteins in CRS	Origin	Sub-cellular	H n = 9 (#avg signal)	CRS n = 10 (avg signal)	P-value (two-tailed t-test)	% of total protein signal in H	% of total protein signal in CRS
Angiotensinogen	Blood	Secreted	6 (−1.87)	7 (0.271)	0.046	0.0339	0.081
Ras-related protein Rab-14 (Fragment)	Others	Others	3 (−3.47)	4 (−0.34)	0.0113	0.0001	0.004
40S ribosomal protein S12	Others	Cytoplasm	3 (−2.81)	4 (0.734)	0.002	0.135	4.399
Protein S100-A9	Immune cells	Cytoplasm	9 (−0.501)	10 (0.277)	0.033	1.998	5.725
Cell division control protein 42 homolog	Others	Others	3 (0.328)	4 (0.194)	0.041	0.023	0.041
Low affinity immunoglobulin gamma Fc region receptor III-B	Immune cells	Membrane	6 (−2.291)	7 (0.428)	0.005	0.005	0.084
Isoform 3 of Protein PRRC2C	Others	Membrane	3 (−5.705)	4 (3.96)	0.00008	0.0001	4.173
Total relative abundance of elevated proteins in CRS							14.5
Total relative abundance of reduced proteins in CRS							9.539
Total relative abundance of elevated and reduced proteins in CRS							24.039

^#Average signal for a protein is calculated as the sample signal minus the internal reference signal, which is then averaged across samples (n = 9 for healthy and n = 10 for CRS).

H- healthy; CRS- chronic rhinosinusitis.