Figure 3.

Effect of P311 on angiogenesis in subcutaneous Matrigel plugs. (A) Representative cross-sections of H&E-stained of the Matrigel plugs, harvested on the 7th day after implantation into P311 WT and P311 KO mice. Scale bars = 200, 50 μm. (B,C) Quantitation of neoangiogenesis. (B) Number of endothelial cell nuclei in the matrigel implants (n = 4 per group). (C) Penetration Index (Penetration of new vessels into the implants, penetration index = area of vessels/overall Matrigel area) (n = 4 per group). Data were expressed as means ± SD. ^**P < 0.01, P311 WT vs. KO. The experiment was repeated for three times with reproducible results.