Table 6. Univariate and multivariate logistic regression analysis of risk factors for ARDS development in severe pneumonia.
| Characteristics | Univariate logistic regression | Multivariate logistic regression | |||
|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | ||
| Disease severity | |||||
| Marshall | 0.877 (0.693–1.108) | 0.271 | – | – | |
| SOFA | 0.873 (0.723–1.054) | 0.157 | – | – | |
| LIS | 3.278 (1.501–7.156) | 0.003 | – | – | |
| Comorbidities (%) | |||||
| Cardiovascular diseases | 0.565 (0.213–1.502) | 0.253 | – | – | |
| Gastrointestinal diseases | 0.181 (0.048–0.684) | 0.012 | 0.095 (0.007–1.349) | 0.082 | |
| Clinical characteristics | |||||
| Disease duration (days) | 0.901 (0.722–1.126) | 0.359 | – | – | |
| Lower extremities edema (%) | 0.451 (0.154–1.320) | 0.146 | – | – | |
| Body temperature (°C) | 1.906 (1.157–3.142) | 0.011 | 1.607 (0.755–3.421) | 0.219 | |
| SpO2 (%) | 0.888 (0.803–0.981) | 0.020 | – | – | |
| Laboratory analysis | |||||
| PaO2/FiO2 (mmHg) | 0.991 (0.983–0.999) | 0.023 | 1.000 (0.985–1.014) | 0.949 | |
| BUN (mmol/L) | 0.914 (0.836–0.998) | 0.046 | 0.930 (0.797–1.085) | 0.356 | |
| FiB (g/L) | 1.357 (1.042–1.769) | 0.024 | 1.893 (1.141–3.142) | 0.014 | |
| Myoglobin (ng/mL) | 0.997 (0.994–1.001) | 0.101 | – | – | |
| CRP (ng/L) | 1.002 (0.998–1.006) | 0.317 | – | – | |
| Treatment strategies | |||||
| Invasive MV (%) | 2.316 (0.585–9.160) | 0.231 | – | – | |
| PEEP (cmH2O) | 1.461 (1.176–1.816) | 0.001 | 1.651 (1.218–2.237) | 0.001 | |
| FiO2 (invasive, %) | 1.030 (1.005–1.056) | 0.020 | – | – | |
| EPAP (cmH2O) | 3.889 (0.574–26.361) | 0.164 | – | – | |
| Midazolam (mg/d) | 1.006 (0.997–1.016) | 0.200 | – | – | |
| Muscle relaxants (%) | 6.714 (1.250–36.061) | 0.026 | 0.483 (0.046–5.104) | 0.483 | |
| Outcomes | |||||
| Delirium (%) | 0.410 (0.081–2.087) | 0.283 | – | – | |
ARDS, acute respiratory distress syndrome; BUN, blood urea nitrogen; CI, confidence interval; CRP, C-reactive protein; EPAP, expiratory positive airway pressure; FiB, fibrinogen; FiO2, fraction of inspired oxygen; LIS, lung injury score; MV, mechanical ventilation; PEEP, positive end-expiratory pressure; OR, odds ratio; PaO2/FiO2, ratio of partial pressure of arterial oxygen to fraction of inspired oxygen; SOFA, sequential organ failure assessment; SpO2, oxygen saturation of pulse oximetry.