WBC and CRP trends in NT. The CRP levels on the sixth and seventh postoperative days were significantly associated with anastomotic leak (P=0.028 and P=0.039, respectively). After esophagogram, the CRP level was also significantly associated with anatomical leak (P=0.008) (presented as 2 standard errors of the mean). WBC, white blood cell; CRP, C-reactive protein; NT, neoadjuvant therapy.