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. 2017 Nov 2;13(12):1489–1496. doi: 10.7150/ijbs.21637

Figure 1.

Figure 1

Schematic represents the factors involved in the USP2's alternative splicing. A. TNF-α, PDGF-BB, TGF-β1, IL-1β, androgen and PKC promote or inhibit USP2-201's alternative splicing by directly or indirectly influencing splicing enhancer (se, orange box) or splicing silencer (ss, green box) which are both located on the pre-mRNA (double dashed line). B. TNF-α inhibits USP2-202's alternative splicing by directly or indirectly influencing splicing silencer (ss, green box) which is located on the pre-mRNA (double dashed line). C. Nutritional signals, Clock, PGC-1α, PKC and Bmal 1 promote or inhibit USP2-204's alternative splicing by directly or indirectly influencing splicing enhancer (se, orange box) or splicing silencer (ss, green box) which are both located on the pre-mRNA (double dotted line). USP2-201, USP2-202, USP2-204 contains 13, 12, 12 exons respectively, of which 11 exons are identical (blue boxes), others are unique to each mRNA (red boxes).