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. 2017 Nov 27;13(12):1547–1559. doi: 10.7150/ijbs.22670

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Model of O₂ supplementation plays an ameliorative role in bone development by promoting angiogensis. O₂ supplementation (relative hyperoxic condition) could enhance the growth of Tibetan chickens and promote bone development by up-regulating angiogenesis related genes expression against high-altitude hypoxia in body suppression. ADFI: average daily feed intake; ADG: average daily weight gain; FCR: Feed conversion ratio; BW: body weight; T.weight: Tibia weight; T. length: tibia length; T. mid-diameter: tibia mid-diameter.