Table 1.
Characteristics of metastatic basal cell carcinoma cases.
| Characteristics | Current study (2012–2017) | Wysong et al. (1981–2011) | von Domarus and Stevens (1894–1980) | Comparison of the studies |
|---|---|---|---|---|
| Total no. of cases | 25 | 194 | 170 | 389 |
| Male, no. (%)a | 20 (80%) | 136 (71%) | 102 (67%) | 258 (66%) |
| Ratio (male : female) | 4 : 1 | 3 : 1 | 2 : 1 | 2 : 1 |
| Age at onset of primary tumor, median (range), yb | 65 (36–83) | 50 (24–88) | 45 (14–84) | — |
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| Location of primary tumor | ||||
|
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| Head and neck | 12 (48%) | 122 (64%) | 119 (75%) | 253 (65%) |
| Trunk | 6 (24%) | 41 (21%) | 26 (17%) | 73 (18.7%) |
| Extremities | 5 (20%) | 10 (5%) | 11 (7%) | 26 (6.6%) |
| Genitalia | 1 (4%) | 10 (5%) | 2 (1%) | 13 (3.3%) |
| Multiple sites | 1 (4%) | 9 (5%) | — | 10 (2.5%) |
| Interval from onset of tumor to metastasis, median (range), yc | 6 (0–18) | 9 (0–30) | 9 (0–45) | — |
| Age at first sign of metastasis, median (range), y | 69 (40–90) | 63 (32–92) | 59 (24–89) | — |
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| Site of metastasisd | ||||
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| Lymph nodes | 14 (56%) | 101 (53%) | 63 (39%) | 178 (45%) |
| Lung | 9 (36%) | 62 (33%) | 66 (42%) | 137 (35%) |
| Parotid gland | 5 (20%) | — | — | 5 (1.2%) |
| Bone | 4 (16%) | 38 (20%) | 44 (28%) | 86 (22%) |
| Submandibular gland | 3 (12%) | — | — | 3 (0.7%) |
| Thyroid | 1 (4%) | — | — | 1 (0.2%) |
| Skin/subcutaneous | 0 | 21 (11%) | 19 (12%) | 40 (10%) |
| Liver | 0 | 8 (4%) | 15 (9%) | 23 (6%) |
| Time to death after diagnosis of metastasis, median (range), moe | 24 (6–300) | 10 (0.5–108) | 8 (1–192) | — |
a N = 25 for current study, N = 191 for study by Wysong et al., and N = 153 for study by von Domarus and Stevens. bN = 22 for current study, N = 157 for study by Wysong et al., and N = 130 for study by von Domarus and Stevens. cN = 21 for current study, N = 152 for study by Wysong et al., and N = 137 for study by von Domarus and Stevens. dForty-seven cases involved more than 1 organ system; N = 25 for current study, N = 190 for study by Wysong et al., N = 159 for study by von Domarus and Stevens. eCases where survival data are available: N = 5 for current study, N = 51 for study by Wysong et al., and N = 79 for study by von Domarus and Stevens.