Figure 3.

Organization of small domains across the cell cycle. (a) Contact maps for the 500-kb genomic region during the cell cycle. Positive border strength scores were defined as borders (red lines). Dotted lines represent the conserved domains across the cell cycle. (b) Domain sizes during the cell cycle. Numbers of the predicted small domains are shown at top. Domain sizes are represented as boxplots. Source data for b are available in Supplementary Data Set 6. (c) Log₂ ratios of contact scores between the indicated consecutive time points were calculated for all genomic contacts within the small domains and represented as boxplots. Source data for c are available in Supplementary Data Set 7. (d) Correlations between contact maps were evaluated using the HiCRep program⁴⁴. Note that genomic contacts were divided into three categories (<75 kb, 75 kb–1 Mb, and >1 Mb) on the basis of distances between two loci and that correlations were calculated for the respective categories. For b and c, all boxplot edges show center quartiles, midlines show medians, and whiskers extend to the data points, which are no more than 1.5× the interquartile range from the box. Circles indicate outliers.