Table 4.
Sensitivity analysis with incidence rates and adjusted incident rate ratios for movement side effects in people with and without ID prescribed first and second-generation antipsychotic drugs
| ID cohort | Non-ID cohort | Comparison | ||||||
| Antipsychotic class | Events during follow-up (n) | Person-years (×10 000) (n) | Incidence per 10 000 person-years (95% CI) | No of events during follow-up | Person-years (×10 000) (n) | Incidence per 10 000 person-years (95% CI) | Incidence rate ratio* (95% CI) | p Value |
| First generation† | 247 | 0.8 | 320 (283 to 362) | 569 | 1.9 | 293 (270 to 318) | 1.36 (1.16 to 1.60) | <0.001 |
| Second generation† | 378 | 1.6 | 241 (218 to 267) | 948 | 4.3 | 219 (206 to 233) | 1.43 (1.26 to 1.62) | <0.001 |
| Risperidone† | 124 | 0.6 | 196 (164 to 233) | 96 | 0.5 | 182 (149 to 223) | 1.55 (1.15 to 2.08) | 0.004 |
*Adjusted for sex, social deprivation score, time period, history of antipsychotic drug use, average daily dose, days on treatment.
†Restricted to periods when people were exclusively prescribed first or second-generation antipsychotic drugs or risperidone.
ID, intellectual disability.