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. 2017 Nov 27;114(49):12940–12945. doi: 10.1073/pnas.1708018114

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Copyright © 2017 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — Cytokine levels in sera, but not in macrophages, are significantly decreased in macrophage-specific Slc39a10^fl/fl;LysM-Cre⁺ mice. (A) The indicated cytokines levels were measured in the sera of Slc39a10^fl/fl;LysM-Cre⁺ and control mice with and without LPS stimulation (n = 5 mice per group). (B) mRNA levels of the indicated cytokines were measured in the spleen of Slc39a10^fl/fl;LysM-Cre⁺ and control mice following LPS stimulation (n = 5 mice per group). (C and D) Protein (C) and mRNA (D) levels of TNF-α, IL-6, and IFN-β were measured in BMDMs of Slc39a10^fl/fl;LysM-Cre⁺ mice and control mice at the indicated times following LPS stimulation (n = 3 mice per group). NT, no treatment. A, C, and D were analyzed by ANOVA, B by t test. *P < 0.05.