Fig. 7.

mDCs from individuals living in an endemic area up-regulate markers but fail to secrete cytokines upon stimulation with P. falciparum. mDCs were enriched from PBMCs from Malian adults and incubated with P. falciparum-iRBCs or uninfected RBC lysates at a ratio of 1:3 [DC:(i)RBC] for 24 h and analyzed for surface marker expression (A) and cytokine secretion (B). Each symbol represents one individual donor and experiment. Line depicts grand mean (*P < 0.05, **P < 0.01, and ***P < 0.001 by Friedman test vs. uninfected RBC control; n = 11).