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. 2017 Dec 11;12:31. doi: 10.1186/s40248-017-0113-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic pharmacokinetic profile of extended-release (ER) vs immediate-release (IR) guaifenesin formulations. Extended-release (ER) guaifenesin (blue line) attained bioequivalent plasma concentrations to those obtained with 3 immediate-release (IR) guaifenesin doses (orange line). The unique bi-layer tablet formulation comprises an IR layer that permits immediate release of guaifenesin to rapidly attain maximum plasma concentrations (C_max), and an ER layer that permits sustained release of guaifenesin to maintain prolonged blood plasma levels of guaifenesin over 12 h. Figure adapted from Vilson and Owen, 2013 [20]