Table 6.

Clinical efficacy studies: Rhinosinusitis

First Author (Year)	Objectives of study	Intervention	Results
Wawrose (1992)	To evaluate the role of guaifenesin in decreasing symptoms of postnasal drainage and nasal congestion in HIV+ patients with chronic rhinosinusitis	Double-blind parallel-group study: 1200 mg guaifenesin vs placebo 2× daily for 3 weeks	Significantly less nasal congestion and thinner postnasal drainage reported after 3 weeks of treatment with guaifenesin vs placebo (p < 0.05)
Rosen (2005)	To evaluate the effect of guaifenesin on mucociliary clearance time (MCT) and sinonasal symptoms in HIV+ patients	Randomized double-blind parallel-group study: 1200 mg guaifenesin vs placebo 2× daily for 3 weeks	Significant improvement in sinonasal symptom survey (SNOT-16) score in HIV+ patients treated with guaifenesin vs placebo (p < 0.05)