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. Author manuscript; available in PMC: 2017 Dec 11.
Published in final edited form as: Cell Rep. 2014 Sep 4;8(5):1571–1582. doi: 10.1016/j.celrep.2014.08.003

Figure 6. TASK-3 modulates the cold sensitivity of TRPM8 neurons.

Figure 6

(A) Mean ± sem calcium elevation evoked by cold, menthol (100 μM), cold plus menthol in TRPM8(+) neurons in wild type (green) and TASK-3KO mice (red) (** for p<0.01 and *** for p<0.001; unpaired t-test). (B) Percentage of TRPM8(+) neurons responding to different agonists in TASK3WT (green) and TASK3KO mice. Cinnamaldehyde (CA, 100 μM), capsaicin (Cap, 100 nM). (C). Temperature threshold of activation of FACSed YFP(+) neurons from TRPM8BAC-EYFP(+/−) and TRPM8BAC-EYFP(+/−); TASK3KO mice (*** for p<0.001; unpaired t-test).