(A) Duration of behaviour (lift, shake, lick) to application of a drop of water (left) or acetone in male wild type (n = 15) or TASK-3KO mice (n = 16) (*** for p<0.001, unpaired t-test). (B) Paw withdrawal latency to application of a dry ice pellet to the bottom face of a glass plate in male wild type (n = 6), TRPA1 KO (n = 9), TRPM8 KO (n = 9) and TASK-3KO mice (n = 11) (* for p<0.05, *** for p<0.001; one way ANOVA and Bonferroni post test) (C) Estimated temperature at the skin surface in the same experiment (* for p<0.05, *** for p<0.001; one way ANOVA and Bonferroni post test).