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. Author manuscript; available in PMC: 2018 Nov 21.
Published in final edited form as: Immunity. 2017 Nov 14;47(5):835–847.e4. doi: 10.1016/j.immuni.2017.10.013

Figure 7. Large numbers of GAP5040–48-specific CD8+ T cells control primary L. monocytogenes infection.

Figure 7

(A) BALB/c mice were infected IV with 5×103 CFU of wt LM or recombinant LM-GAP5040–48. Bacterial burden was measured in the spleen on day 5. Data represent two independent experiments (n = 4 mice/group). Bars depict mean ± SD. (B) C57Bl/6 mice were infected IV with 104 CFU of wt LM or recombinant LM-GAP5040–48. Bacterial burden was measured in the spleen on day 5. Cumulative results are shown from three independent experiments (total n = 14–15 mice/group). Bars depict mean ± SEM. Significance was assessed using an unpaired, two-tailed t test (****p<0.0001). (C) Representative flow cytometry plots showing H-2Db-GAP5040–48 tetramer staining of splenocytes isolated from infected C57Bl/6 mice at day 5 post-infection.