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Adaptive evolution in the absence of coinfection and when selection acts only on the antigenic gene segment. Results are presented from a representative simulation. (A) Fitness variation in the viral population over time. (B) Mean (log) fitness of the virus population over time. (C) Antigenic gene genealogy reconstructed from model simulation by sampling 300 singly infected individuals over 20 years, following a burn-in of 40 years.
