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. Author manuscript; available in PMC: 2017 Dec 11.
Published in final edited form as: Biomaterials. 2012 Apr 6;33(19):4957–4964. doi: 10.1016/j.biomaterials.2012.03.041

Fig. 2.

Fig. 2

Humoral and cellular responses after vaccination with liposomes and PLGA nanoparticles. Mice (N = 4) were subcutaneously administered a single dose of 100 μg of OVA encapsulated in liposomes or PLGA nanoparticles. Mice were bled approximately every 2 weeks and analyzed for antigen-specific (A) total IgG, (B) IgG1, and (C) IgG2b titers by ELISA. At 11 weeks, splenocytes were pulsed ex vivo with OVA at 25 and 50 μg/mL and analyzed for (D) IFN-γ in the supernatant after 72 h by ELISA. Data shown are from a single experiment that was performed twice with the same results. * Indicate P value less than 0.05.