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Subtypes of MND and relevant pathophysiology (adapted from Miller & Britton, 2011). (++)classic feature; (+)rare feature; (−)not associated.
| PMA | PLS | PBP | ALS | ||
|---|---|---|---|---|---|
| Motor Neuron Involvement | Upper Motor Neuron (UMN) | − | ++ | ++ | ++ |
| Lower Motor Neuron (LMN) | ++ | − | ++ | ++ | |
| Affected Muscle Group | Spinal | ++ | ++ | − | ++ |
| Bulbar | + | ++ | ++ | ++ | |
