Table 3.

Least squares mean change from baseline in the UPDRS total score, UPDRS part II, III, and IV scores, and the PDQ‐39 Summary Index^a

	Baseline N = 37	D7 N = 36	Week 12 N = 34	Week 36 N = 32	Week 60 N = 28
UPDRS total scoreb	43.3 ± 17.8	−8.8 ± 1.5***	−11.4 ± 1.7*	−7.1 ± 1.9***	−7.7 ± 2.3**
UPDRS I	1.6 ± 1.6	−0.6 ± 0.2**	−0.3 ± 0.3	−0.3 ± 0.3	−0.1 ± 0.3
UPDRS II	16.7 ± 6.5	−4.8 ± 0.7***	−5.5 ± 0.9***	−4.2 ± 0.9***	−4.7 ± 0.9***
UPDRS III	25.0 ± 13.2	−3.5 ± 1.2**	−5.6 ± 1.2***	−2.6 ± 1.5	−3.6 ± 1.5**
UPDRS IVc	8.7 ± 3.0	−2.7 ± 0.5***	−3.5 ± 0.4***	−3.5 ± 0.4***	−2.9 ± 0.6***
UPDRS dyskinesia itemsd	3.0 ± 2.1	−1.1 ± 0.4**	−1.1 ± 0.3***	−1.1 ± 0.3***	−0.6 ± 0.4
PDQ‐39 SI	34.7 ± 13.0	−4.8 ± 1.8*	−11.2 ± 2.8***	−9.1 ± 2.2***	−10.2 ± 2.6***

D, day; LS, least squares; PDQ‐39 SI, Parkinson's Disease Questionnaire 39‐tem Summary Index; UPDRS, Unified Parkinson's Disease Rating Scale; Values compared to baseline with paired t‐test, P < 0.001 (***), 0.01 (**), 0.05 (*).

^aAll values depict LS mean ± standard error with the exception of the baseline values which represent the mean ± standard deviation.

^bUPDRS was collected in the “On” state.

^cBaseline, n = 38; D7, n = 37; Week 12, n = 35.

^dItems 32, 33, 34.