A, tumor growth curves in orthotopic mouse model oral tongues bearing PC13-G245D cells with high-risk mutant TP53 following treatment with either vorinostat (65 mg/kg), AZD1775 alone (45 mg/kg) or in combination. B, Kaplan-Meier analysis for overall survival. C, phospho-CDK1 (tyr15) expression levels in the orthotopic tongue tumors. D, Quantification of phospho-CDK1 levels shown in Figure 5C. E and F, CD31 immunohistochemistry and quantification of microvessel density. G and H, TUNEL-positive apoptotic cells in tissue sections obtained from tumors of mice treated with drugs as indicated.