Effect of surface roughness, total implant-bone area and implant diameter on titanium (Ti) released into the bone during insertion. (a) Amount of Ti released (µg) from a machined surface compared with a TiUnite surface with the same 3.75 mm diameter and compensations for the bone-implant area made, but different surface roughness Sa = 0.9 vs. 1.1. Statistical analysis with linear regression show a correlation between surface roughness and Ti release, r
2 = 0.457, p < .001 (n = 29). (b) Amount of Ti released (µg) from implants with same surface roughness, but different bone-implant area. Linear regression shows a weak correlation between bone-implant area and Ti release, r
2 = 0.200, p = .020 (n = 27). (c) Amount of Ti released (µg) from implants with the same surface roughness and compensations for the bone-implant area made, but with different implant diameters, 3.75 vs. 4.0 mm. Linear regression show a no correlation between implant diameter and Ti release, r
2 = 0.121, p =.076 (n = 27).