Fig 8. CT51 inhibits the sustained Ca²⁺ increase induced by the RyR-agonist 4-CMC.

Ca²⁺ signals elicited by the RyR agonist 4-CMC in rat primary hippocampal neurons incubated for 24 h in the absence (open symbols) or the presence of 1 μM CT51 (solid symbols) were determined as a function of time. The graph shows the fluorescence values expressed as F/F₀, where F₀ represents the basal fluorescence recorded before 4-CMC addition. Values represent Mean ± SE; n = 3.