Table 2. Apparent K_ds (nM) for peptides binding to Mdm2/Mdm4 N-terminal domains and indicated variants.

No significant variations are observed for binding of peptides to Mdm2-M62A (used in structural studies) compared to Mdm2. Values represent average ± SD (n = 2). Previously reported values are 34.35 ± 2.03 (_*), 6.76 ± 2.11(_**), 45.73 ± 7.65 (#) and 1360 ± 600 nM (##) [8].

	Mdm2	Mdm2-M62A	Mdm4	Mdm4-L98V
PM2	50.73 ± 12.27*	34.40 ± 7.90	100.89 ± 9.29#	72.32 ± 2.45
M011	6.61 ± 5.06**	6.337 ± 2.92	334.53 ± 45.17##	72.35 ± 7.91
M011-L	132.07 ± 55.79	39.79 ± 10.39	1388.07 ± 511.62	594.43 ± 40.51
VIP160	9.04 ± 1.11	11.05 ± 1.06	193.63 ± 9.15	76.12 ± 6.29
M012	17.847 ± 5.34	14.706 ± 7.24	1785 ± 310.14	385.03 ± 89.75
M012-L	13.21 ± 2.00	9.72 ± 2.52	410.8 ± 51.77	165.47 ± 26.52