Fig 2. Positions belonging to and in close contact with the main pocket.

Exon: shows the limits of each exon. Region: informs the conserved regions involved in catalytic control. Abbreviations: CS: catalytic spine; ADi, SDi: assymetric/symmetric dimer interface; RS: regulatory spine; GK: gatekeeper. Position, list number and residue for each position in the main pocket and close contact. P/C: depicts whether a position is considered as part of the main pocket (P) or in close contact (C). Position and P/C rows are coloured, according to the considerations in P/C, for those sites with defined coordinates in all the structures used in the present work. Those in white correspond to positions that are found as missing in at least one of these structures.